Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation-Reference-Cited by-同舟云学术

Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation

Published:2022-03-11 Issue:4 Volume:13 Page:681-686
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

O’Mahony Gavin¹^ORCID,Petersen Jens²,Ek Margareta²,Rae Rebecca³,Johansson Carina²,Jianming Liu⁴,Prokoph Nina⁴,Bergström Fredrik⁵,Bamberg Krister⁶,Giordanetto Fabrizio¹^ORCID,Zarrouki Bader⁶,Karlsson Daniel⁶,Hogner Anders¹^ORCID

Affiliation:

1. Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43183, Sweden

2. Mechanistic and Structural Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg 43183, Sweden

3. Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg 43183, Sweden

4. Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg 43183, Sweden

5. DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43183, Sweden

6. Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43183, Sweden

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00715

Reference32 articles.

1. Physiological and Therapeutic Roles of Peroxisome Proliferator-Activated Receptors

2. Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage

3. Targeting Peroxisome Proliferator-Activated Receptors (PPARs): Development of Modulators

4. The PPARs: From Orphan Receptors to Drug Discovery

5. An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

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