Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3
Author:
Affiliation:
1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
Funder
National Health and Medical Research Council
Australian Research Council
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00253
Reference35 articles.
1. Neutrophil recruitment and function in health and inflammation
2. Neutrophil Function: From Mechanisms to Disease
3. Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases
4. Global Substrate Profiling of Proteases in Human Neutrophil Extracellular Traps Reveals Consensus Motif Predominantly Contributed by Elastase
5. Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)
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