Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE2 Levels-Reference-Cited by-同舟云学术

Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE2 Levels

Published:2020-03-05 Issue:5 Volume:11 Page:783-789
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Chini Maria G.¹²,Giordano Assunta¹³,Potenza Marianna¹,Terracciano Stefania¹,Fischer Katrin⁴,Vaccaro Maria C.¹,Colarusso Ester¹,Bruno Ines¹,Riccio Raffaele¹,Koeberle Andreas⁴⁵,Werz Oliver⁴^ORCID,Bifulco Giuseppe¹^ORCID

Affiliation:

1. Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084, Fisciano, Italy

2. Department of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, Pesche, Isernia, I-86090, Italy

3. Institute of Biomolecular Chemistry (ICB), Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, I-80078, Pozzuoli, Napoli, Italy

4. Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena, Germany

5. Michael Popp Research Institute, University of Innsbruck, Innsbruck, Austria

Funder

Associazione Italiana per la Ricerca sul Cancro

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00618

Reference37 articles.

1. Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions

2. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

3. From inflammation to cancer

4. mPGES-1 as a target for cancer suppression

5. Transition from inflammation to proliferation: a critical step during wound healing

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