Discovery of a Novel Series of Pyridone-Based EP3 Antagonists for the Treatment of Type 2 Diabetes
Author:
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00667
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1. Genetic and pharmacological analysis of prostanoid receptor function
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3. Prostaglandin E Receptors
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5. Enhanced bladder capacity and reduced prostaglandin E2-mediated bladder hyperactivity in EP3 receptor knockout mice
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1. Discovery of Thieno[2,3-e]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability;Journal of Medicinal Chemistry;2022-03-31
2. Discovery and Optimization of 7-Alkylidenyltetrahydroindazole-Based Acylsulfonamide EP3 Antagonists;ACS Medicinal Chemistry Letters;2021-12-07
3. Optimization of physicochemical properties of pyridone-based EP3 receptor antagonists;Bioorganic & Medicinal Chemistry Letters;2021-09
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