Evaluation of 3-Dimensionality in Approved and Experimental Drug Space
Author:
Affiliation:
1. Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States
Funder
National Institute of Allergy and Infectious Diseases
Division of Graduate Education
Natural Sciences and Engineering Research Council of Canada
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00121
Reference44 articles.
1. Specific Noncovalent Interactions at Protein-Ligand Interface: Implications for Rational Drug Design
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3. Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology
4. Binding of Small-Molecule Ligands to Proteins: “What You See” Is Not Always “What You Get”
5. Conformational Analysis of Drug-Like Molecules Bound to Proteins: An Extensive Study of Ligand Reorganization upon Binding
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