Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist-Reference-Cited by-同舟云学术

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

Published:2020-03-31 Issue:6 Volume:11 Page:1221-1227
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Cherney Robert J.¹^ORCID,Cornelius Lyndon A. M.¹,Srivastava Anurag¹,Weigelt Carolyn A.¹,Marcoux David¹^ORCID,Duan James J.-W.¹^ORCID,Shi Qing¹^ORCID,Batt Douglas G.¹,Liu Qingjie¹,Yip Shiuhang¹,Wu Dauh-Rurng¹,Ruzanov Max¹,Sack John¹,Khan Javed¹,Wang Jinhong¹,Yarde Melissa¹,Cvijic Mary Ellen¹,Mathur Arvind¹,Li Sha¹,Shuster David¹,Khandelwal Purnima¹,Borowski Virna¹,Xie Jenny¹,Obermeier Mary¹,Fura Aberra¹,Stefanski Kevin¹,Cornelius Georgia¹,Tino Joseph A.¹,Macor John E.¹,Salter-Cid Luisa¹,Denton Rex¹,Zhao Qihong¹,Carter Percy H.¹^ORCID,Dhar T. G. Murali¹^ORCID

Affiliation:

1. Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00063

Reference30 articles.

2. The Emerging Landscape of RORγt Biology

3. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

4. The IL-17 Family Cytokines in Immunity and Disease

5. Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

Cited by 33 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Binary Organic Solar Cells with Exceeding 19% Efficiency via the Synergy of Polyfluoride Polymer and Fluorous Solvent;Advanced Materials;2024-05-19

2. Small-molecule agents for treating skin diseases;European Journal of Medicinal Chemistry;2024-03

3. Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development;Journal of Medicinal Chemistry;2024-01-03

4. A comprehensive review of discovery and development of drugs discovered from 2020–2022;Saudi Pharmaceutical Journal;2024-01

5. Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels;Antiviral Research;2024-01