Synthesis and Evaluation of Neutral Phosphate Triester Backbone-Modified siRNAs-Reference-Cited by-同舟云学术

Synthesis and Evaluation of Neutral Phosphate Triester Backbone-Modified siRNAs

Published:2020-06-09 Issue:7 Volume:11 Page:1457-1462
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Tsubaki Kouta¹²,Hammill Matthew L.²,Varley Andrew J.²,Kitamura Mitsuru¹,Okauchi Tatsuo¹^ORCID,Desaulniers Jean-Paul²^ORCID

Affiliation:

1. Department of Applied Chemistry, Graduate School of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata, Kitakyushu 804-8550, Japan

2. Faculty of Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, Ontario L1G 0C5, Canada

Funder

Natural Sciences and Engineering Research Council of Canada

Institute of Rheological Functions of Food in Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00232

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1. Leading RNA Interference Therapeutics Part 2: Silencing Delta-Aminolevulinic Acid Synthase 1, with a Focus on Givosiran

2. Oligonucleotides to the (Gene) Rescue: FDA Approvals 2017–2019

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4. Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes

5. Functional siRNAs and miRNAs Exhibit Strand Bias

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