Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases-Reference-Cited by-同舟云学术

Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases

Published:2020-09-28 Issue:11 Volume:11 Page:2261-2267
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Toulouse Jacynthe L.¹²³,Shi Genbin⁴,Lemay-St-Denis Claudèle¹²³^ORCID,Ebert Maximilian C. C. J. C.⁵,Deon Daniel⁶,Gagnon Marc⁶,Ruediger Edward⁶,Saint-Jacques Kévin⁷,Forge Delphine⁸,Vanden Eynde Jean Jacques⁸,Marinier Anne⁶,Ji Xinhua⁴^ORCID,Pelletier Joelle N.¹²³¹^ORCID

Affiliation:

1. Département de biochimie, Université de Montréal, Montréal, Quebec H3T 1J4, Canada

2. PROTEO, Quebec G1V 0A6, Canada

3. CGCC, Center in Green Chemistry and Catalysis, Montréal, Quebec H2V 0B3, Canada

4. Macromolecular Crystallography Laboratory, NCI, Frederick, Maryland 21702, United States;

5. Chemical Computing Group ULC, Montréal, Quebec H3A 2R7, Canada

6. Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Quebec H3T 1J4, Canada

7. Département de chimie, Université de Sherbrooke, Sherbrooke, Quebec J1K 2R1, Canada

8. Laboratoire de chimie organique, Université de Mons, 7000 Mons, Belgium

Funder

Hydro-Qu??bec

Canada Foundation for Innovation

Fonds Qu??b??cois de la Recherche sur la Nature et les Technologies

Universit?? de Montr??al

Government of Canada

Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research

Fondation Marcel et Rolande Gosselin

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00393

Reference44 articles.

1. Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery

2. An Innovative Strategy for Dual Inhibitor Design and Its Application in Dual Inhibition of Human Thymidylate Synthase and Dihydrofolate Reductase Enzymes

3. Design, Synthesis, and Antimicrobial Evaluation of a New Series of N-Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes

4. Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agentFrancisella tularensis

5. Giguère, S.; Prescott, J. F.; Dowling, P. M. Antimicrobial therapy in veterinary medicine; John Wiley & Sons Inc, 2013; Vol. 47, pp 256–257.

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