Design of Novel Series of Antimalarial PMX Inhibitors with Increased Half-Life via Molecular Property Optimization
Author:
Affiliation:
1. UCB, 216 Bath Road, Slough SL1 3WE, United Kingdom
2. UCB, Chem. du Foriest 1, 1420 Braine-l’Alleud, Belgium
3. Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215 Geneva, Switzerland
Funder
UCB
Medicines for Malaria Venture
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00404
Reference25 articles.
1. Malaria parasite plasmepsins: More than just plain old degradative pepsins
2. Proteases in Malaria Parasites - A Phylogenomic Perspective
3. Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present)
4. A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress
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