Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization-Reference-Cited by-同舟云学术

Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization

Published:2023-06-12 Issue:7 Volume:14 Page:929-935
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Chupak Louis¹^ORCID,Wichroski Michael¹,Zheng Xiaofan¹,Ding Min¹,Martin Scott¹,Allard Christopher¹,Shi Jianliang²,Gentles Robert¹,Meanwell Nicholas A.²^ORCID,Fang Jie²,Tenney Daniel²,Tokarski John²,Cao Carolyn²,Wee Susan²

Affiliation:

1. Bristol Myers Squibb Research and Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States

2. Bristol Myers Squibb Research and Early Development, PO Box 4000, Princeton, New Jersey 08543-4000, United States

Funder

Bristol-Myers Squibb

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00063

Reference39 articles.

1. Regulation and Functions of Diacylglycerol Kinases

2. Beyond Lipid Signaling: Pleiotropic Effects of Diacylglycerol Kinases in Cellular Signaling

3. Diacylglycerol-dependent Binding Recruits PKCθ and RasGRP1 C1 Domains to Specific Subcellular Localizations in Living T Lymphocytes

4. Decreased Diacylglycerol Metabolism Enhances ERK Activation and Augments CD8+ T Cell Functional Responses

5. Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy

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