Novel Indane-Containing NBTIs with Potent Anti-Gram-Negative Activity and Minimal hERG Inhibition
Author:
Affiliation:
1. Roche Pharma Research & Early Development, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland;
2. China Innovation Center of Roche, Roche R&D Center (China) Ltd., Shanghai 201203, China;
3. Aptuit, an Evotec Company, 37135 Verona, Italy.
Funder
Roche
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00422
Reference22 articles.
1. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis
2. Type IIA topoisomerase inhibition by a new class of antibacterial agents
3. Mechanism of Action of the Antibiotic NXL101, a Novel Nonfluoroquinolone Inhibitor of Bacterial Type II Topoisomerases
4. Novel Bacterial Topoisomerase inhibitors (NBTIs) – A comprehensive review
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