Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties-Reference-Cited by-同舟云学术

Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties

Published:2018-10-19 Issue:12 Volume:9 Page:1205-1210
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

David Hong W.¹,Leung Suet C.²,Amporndanai Kangsa³,Davies Jill²,Priestley Richard S.²,Nixon Gemma L.¹^ORCID,Berry Neil G.¹,Samar Hasnain S.³,Antonyuk Svetlana³,Ward Stephen A.²,Biagini Giancarlo A.²,O’Neill Paul M.¹

Affiliation:

1. Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, U.K.

2. Research Centre for Drugs & Diagnostics, Parasitology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, U.K.

3. Molecular Biophysics Group, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00371

Reference31 articles.

1. WHO. World Malaria Report 2017. https://www.who.int/malaria/publications/world-malaria-report-2017/en/.

2. The State of the Art in Anti-Malarial Drug Discovery and Development

3. Quinolines and structurally related heterocycles as antimalarials

4. 1,2-Substituted 4-(1H)-Quinolones: Synthesis, Antimalarial and Antitrypanosomal Activities in Vitro

5. Synthesis of 4-Hydroxy-2(1H)-Quinolone Derived Chalcones, Pyrazolines and Their Antimicrobial, In Silico Antimalarial Evaluations

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