Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer’s Disease

Author:

De Simone Angela1,La Pietra Valeria2,Betari Nibal1,Petragnani Nicola3,Conte Mariarosaria4,Daniele Simona5,Pietrobono Deborah5,Martini Claudia5ORCID,Petralla Sabrina6,Casadei Raffaella1,Davani Lara1,Frabetti Flavia7,Russomanno Pasquale2,Novellino Ettore2ORCID,Montanari Serena1,Tumiatti Vincenzo1,Ballerini Patrizia3,Sarno Federica8,Nebbioso Angela8,Altucci Lucia8,Monti Barbara6,Andrisano Vincenza1,Milelli Andrea1ORCID

Affiliation:

1. Department for Life Quality Studies, Alma Mater Studiorum—University of Bologna, Corso d’Augusto 237, 47921 Rimini, Italy

2. Department of Pharmacy, Federico II University of Naples, Via D. Montesano 49, 80131 Naples, Italy

3. Department of Psychological, Health and Territorial Sciences, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini 32, 66100 Chieti, Italy

4. IRCCS, SDN, Via E. Gianturco 113, 80143 Naples, Italy

5. Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy

6. Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy

7. Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum-University of Bologna, Via Belmeloro 8, 40126 Bologna, Italy

8. Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138 Naples, Italy

Funder

FP7 Health

Worldwide Cancer Research

Ministero dell?Istruzione, dell?Universit? e della Ricerca

Associazione Italiana per la Ricerca sul Cancro

Universit? di Bologna

Consiglio Nazionale delle Ricerche

European Cooperation in Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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