Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor-Reference-Cited by-同舟云学术

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor

Published:2018-01-24 Issue:2 Volume:9 Page:143-148
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Zheng Barbara¹^ORCID,D’Andrea Stanley V.¹,Sun Li-Qiang¹,Wang Alan Xiangdong¹,Chen Yan¹,Hrnciar Peter¹,Friborg Jacques¹,Falk Paul¹,Hernandez Dennis¹,Yu Fei¹,Sheaffer Amy K.¹,Knipe Jay O.¹,Mosure Kathy¹,Rajamani Ramkumar¹,Good Andrew C.¹,Kish Kevin²,Tredup Jeffrey²,Klei Herbert E.²,Paruchuri Manjula³,Ng Alicia¹,Gao Qi¹,Rampulla Richard A.⁴,Mathur Arvind⁴,Meanwell Nicholas A.¹^ORCID,McPhee Fiona¹,Scola Paul M.¹

Affiliation:

1. Research and Development, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, Connecticut 06492, United States

2. Research and Development, Bristol-Myers Squibb, PO Box 5400, Princeton, New Jersey 08543, United States

3. Biologics Process Development, Bristol-Myers Squibb, 311 Pennington Rocky Hill Road, Pennington, New Jersey 08534, United States

4. Discovery Synthesis, Research and Development, Bristol-Myers Squibb, Route 206 and Province Line Road, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00503

Reference23 articles.

1. Current therapy for chronic hepatitis C: The role of direct-acting antivirals

2. Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1

3. Daclatasvir + Asunaprevir: First Global Approval

4. The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

5. Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

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