Rational Design of a Cytotoxic Dinuclear Cu2 Complex That Binds by Molecular Recognition at Two Neighboring Phosphates of the DNA Backbone

Author:

Jany Thomas1,Moreth Alexander1,Gruschka Claudia1,Sischka Andy1,Spiering Andre1,Dieding Mareike1,Wang Ying1,Samo Susan Haji1,Stammler Anja1,Bögge Hartmut1,Fischer von Mollard Gabriele1,Anselmetti Dario1,Glaser Thorsten1

Affiliation:

1. Lehrstuhl für Anorganische Chemie I, Chemistry Department, ‡Lehrstuhl für Biochemie III, Chemistry Department, and §Experimentelle Biophysik, Physics Department, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Inorganic Chemistry,Physical and Theoretical Chemistry

Reference91 articles.

1. Multiplicity of metal ion binding patterns to nucleobases

2. bDerose, V. J.; Burns, S.; Kim, N.K.; Vogt, N.InComprehensive Coordination Chemistry II;McCleverty, J. A.; Meyer, T. J., Eds.Elsevier, Ltd.:Oxford, 2004; Vol.8, pp787–813.

3. Nucleic Acid-Metal Ion Interactions

4. Interplay between Metal Ions and Nucleic Acids

5. Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme

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