An Annulative Approach to Highly Substituted Indoles:  Unusual Effect of Phenolic Additives on the Success of the Arylation of Ketone Enolates

Author:

Rutherford Jennifer L.1,Rainka Matthew P.1,Buchwald Stephen L.1

Affiliation:

1. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference16 articles.

1. For reviews on indole syntheses:  (a) Sundberg, R. J.Indoles; Academic Press:  San Diego, 1996. (b) Gribble, G. W.J. Chem. Soc., Perkin Trans. 12000, 1045. (c) Gilchrist, T. L.J. Chem. Soc., Perkin Trans. 12001, 2491.

2. Palladium-catalyzed annulation

3. Syntheses of Indoles via a Palladium-Catalyzed Annulation between Iodoanilines and Ketones

4. Indole synthesis by radical cyclization ofo-alkenylphenyl isocyanides and its application to the total synthesis of natural products

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