Safer Solvents for Active Pharmaceutical Ingredient Purification Using Column Chromatography

Author:

Ayafor Christian1ORCID,Burton Toren2,George Nathaniel2,Morose Gregory3,Wong Hsi-Wu2ORCID

Affiliation:

1. Energy Engineering Program, University of Massachusetts Lowell, Lowell, Massachusetts 01854, United States

2. Department of Chemical Engineering, University of Massachusetts Lowell, Lowell, Massachusetts 01854, United States

3. Massachusetts Toxics Use Reduction Institute, Lowell, Massachusetts 01854, United States

Funder

Massachusetts Toxic Use Reduction Institute

Publisher

American Chemical Society (ACS)

Reference50 articles.

1. U.S. Department of Health and Human Services, National Toxicology Program: 15th Report on Carcinogens. National Toxicology Program (NTP). https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dichloromethane.pdf (accessed May- 20, 2024).

2. Office of Chemical Safety and Pollution Prevention, U.S. Environmental Protection Agency. Fact Sheet: Methylene Chloride or Dichloromethane (DCM). https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/fact-sheet-methylene-chloride-or-dichloromethane-dcm-0 (accessed May 20, 2024).

3. Office of Chemical Safety and Pollution Prevention, U.S. Environmental Protection Agency. Risk Evaluation for Methylene Chloride (Dichloromethane, DCM) CASRN: 75–09–2. 2020. https://www.epa.gov/sites/default/files/2020-06/documents/1_mecl_risk_evaluation_final.pdf (accessed May 20, 2024).

4. Massachusetts Department of Environmental Protection Toxics Use Reduction Act (TURA) Data and Results. https://www.mass.gov/lists/massdep-toxics-use-reduction-act-tura-data-results (accessed May 20, 2024).

5. Office of Research & Development. IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Final Report # EPA/635/R-10/003F); U.S. Environmental Protection Agency: Washington, DC, 2011.

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