Structural Modifications to Tetrahydropyridine-3-carboxylate Esters en Route to the Discovery of M5-Preferring Muscarinic Receptor Orthosteric Antagonists-Reference-Cited by-同舟云学术

Structural Modifications to Tetrahydropyridine-3-carboxylate Esters en Route to the Discovery of M5-Preferring Muscarinic Receptor Orthosteric Antagonists

Published:2013-02-18 Issue:4 Volume:56 Page:1693-1703
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zheng Guangrong¹,Smith Andrew M.²,Huang Xiaoqin²,Subramanian Karunai L.²,Siripurapu Kiran B.²,Deaciuc Agripina²,Zhan Chang-Guo²,Dwoskin Linda P.²

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States

2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301774u

Reference49 articles.

1. Muscarinic Receptors—Characterization, coupling and function

2. Muscarinic Acetylcholine Receptor Knockout Mice: Novel Phenotypes and Clinical Implications

3. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

4. Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

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