Neocarzilin Inhibits Cancer Cell Proliferation via BST-2 Degradation, Resulting in Lipid Raft-Trapped EGFR

Author:

Braun Josef1,Hu Yudong2,Jauch Adrian T.2,Gronauer Thomas F.13,Mergner Julia4,Bach Nina C.1,Traube Franziska R.5,Zahler Stefan2ORCID,Sieber Stephan A.1ORCID

Affiliation:

1. TUM School of Natural Sciences, Department of Bioscience, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Ernst-Otto-Fischer Straße 8, Garching near Munich D-85748, Germany

2. Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University in Munich (LMU), Butenandtstraße 5-13, Munich D-81377, Germany

3. Metabolomics and Proteomics Core (MPC), Helmholtz Zentrum München GmbH German Research Center for Environmental Health, Heidemannstr. 1, Munich D-80939, Germany

4. Bavarian Center for Biomolecular Mass Spectrometry at Klinikum rechts der Isar (BayBioMS@MRI), Technical University of Munich (TUM), Einsteinstraße 25 Munich, D-81675, Germany

5. Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, Stuttgart D-70569, Germany

Funder

Deutsche Forschungsgemeinschaft

China Scholarship Council

Stiftung der Deutschen Wirtschaft

Publisher

American Chemical Society (ACS)

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