Novel 4,4-Disubstituted Piperidine-Based C–C Chemokine Receptor-5 Inhibitors with High Potency against Human Immunodeficiency Virus-1 and an Improved human Ether-a-go-go Related Gene (hERG) Profile-Reference-Cited by-同舟云学术

Novel 4,4-Disubstituted Piperidine-Based C–C Chemokine Receptor-5 Inhibitors with High Potency against Human Immunodeficiency Virus-1 and an Improved human Ether-a-go-go Related Gene (hERG) Profile

Published:2011-05-17 Issue:11 Volume:54 Page:3756-3767
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kazmierski Wieslaw M.¹,Anderson Don L.¹,Aquino Christopher¹,Chauder Brian A.¹,Duan Maosheng¹,Ferris Robert¹,Kenakin Terrence¹,Koble Cecilia S.¹,Lang Dan G.¹,Mcintyre Maggie S¹,Peckham Jennifer¹,Watson Christian¹,Wheelan Pat¹,Spaltenstein Andrew¹,Wire Mary B.¹,Svolto Angilique¹,Youngman Michael¹

Affiliation:

1. Infectious Diseases Center for Excellence in Drug Discovery, ‡Molecular Discovery Research, §ID DMPK, ∥Metabolic Pathways Center for Excellence in Drug Discovery, ⊥Department of Biochemical and Analytical Pharmacology, and #Clinical Pharmacokinetics CPMS-US, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, North Carolina 27709, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200279v

Reference34 articles.

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2. Highly Potent and Orally Active CCR5 Antagonists as Anti-HIV-1 Agents: Synthesis and Biological Activities of 1-Benzazocine Derivatives Containing a Sulfoxide Moiety

3. The Discovery of the CCR5 Receptor Antagonist, UK-427,857, A New Agent for the Treatment of HIV Infection and AIDS

4. CCR5 Chemokine Receptors: Gatekeepers of HIV-1 Infection

5. Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors

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