Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation-Reference-Cited by-同舟云学术

Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation

Published:2012-10-01 Issue:21 Volume:55 Page:9331-9345
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mandal Mihirbaran¹,Zhu Zhaoning¹,Cumming Jared N.¹,Liu Xiaoxiang¹,Strickland Corey¹,Mazzola Robert D.¹,Caldwell John P.¹,Leach Prescott¹,Grzelak Michael¹,Hyde Lynn¹,Zhang Qi¹,Terracina Giuseppe¹,Zhang Lili¹,Chen Xia¹,Kuvelkar Reshma¹,Kennedy Matthew E.¹,Favreau Leonard¹,Cox Kathleen¹,Orth Peter¹,Buevich Alexei¹,Voigt Johannes¹,Wang Hongwu¹,Kazakevich Irina¹,McKittrick Brian A.¹,Greenlee William¹,Parker Eric M.¹,Stamford Andrew W.¹

Affiliation:

1. Department of Medicinal Chemistry, ‡Department of Neuroscience, §Global Structural Chemistry, ∥Department of Analytical Chemistry, ⊥Department of Basic Pharmaceutical Sciences, and #Department of Exploratory Drug Metabolism, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301039c

Reference72 articles.

1. Current Treatment for Alzheimer Disease and Future Prospects

2. Mechanisms Behind the Neuroprotective Actions of Cholinesterase Inhibitors in Alzheimer Disease

3. Efficacy and Safety of Memantine in Moderate-to-Severe Alzheimer Disease: The Evidence to Date

4. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

5. The amyloid cascade hypothesis

Cited by 55 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chalcone-based dipolar cycloaddition of novel heteroaromatic compounds: Their anticancer examination;Journal of Molecular Structure;2023-12

2. Cosolvent Simulations with Fragment-Bound Proteins Identify Hot Spots to Direct Lead Growth;Journal of Chemical Theory and Computation;2022-05-09

3. Finding Cures for Alzheimer's Disease;Contemporary Accounts in Drug Discovery and Development;2022-03-07

4. In silico screening of potential β-secretase (BACE1) inhibitors from VIETHERB database;Journal of Molecular Modeling;2022-02-14

5. Unprecedented Reversal of Regioselectivity during Methanolysis and an Interception of Curtius Rearrangement;European Journal of Organic Chemistry;2021-09-24