Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume-Reference-Cited by-同舟云学术

Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume

Published:2009-06-09 Issue:13 Volume:52 Page:3846-3854
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Acton John J.¹,Akiyama Taro E.¹,Chang Ching H.¹,Colwell Lawrence¹,Debenham Sheryl¹,Doebber Thomas¹,Einstein Monica¹,Liu Kun¹,McCann Margaret E.¹,Moller David E.¹,Muise Eric S.¹,Tan Yugen¹,Thompson John R.¹,Wong Kenny K.¹,Wu Margaret¹,Xu Libo¹,Meinke Peter T.¹,Berger Joel P.¹,Wood Harold B.¹

Affiliation:

1. Merck Research Laboratories, Merck & Co., Inc., RY800-C114, P.O. Box 2000, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900097m

Reference34 articles.

1. Troglitazone

2. Rosiglitazone

3. Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure

4. Therapeutic index for rosiglitazone in dietary obese rats: separation of efficacy and haemodilution

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