Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease-Reference-Cited by-同舟云学术

Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease

Published:2015-02-26 Issue:4 Volume:14 Page:1854-1871
ISSN:1535-3893
Container-title:Journal of Proteome Research
language:en
Short-container-title:J. Proteome Res.

Author:

James Emma L.¹,Michalek Ryan D.²,Pitiyage Gayani N.¹,de Castro Alice M.¹,Vignola Katie S.²,Jones Janice²,Mohney Robert P.²,Karoly Edward D.²,Prime Stephen S.¹,Parkinson Eric Kenneth¹

Affiliation:

1. Centre for Clinical & Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, United Kingdom

2. Metabolon, Inc., 617 Davis Drive, Suite 400, Durham, North Carolina 27713, United States

Funder

Molecular and Cellular Medicine,Blizard Institute

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/pr501221g

Reference80 articles.

1. A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

2. Cellular Senescence in Aging Primates