Stereoselective Metabolism of the Environmental Mammary Carcinogen 6-Nitrochrysene to trans-1,2-Dihydroxy-1,2-dihydro-6-nitrochrysene by Aroclor 1254-Treated Rat Liver Microsomes and Their Comparative Mutation Profiles in a lacI Mammary Epithelial Cell Line

Author:

Sun Yuan-Wan1,Guttenplan Joseph B.1,Khmelnitsky Michael1,Krzeminski Jacek1,Boyiri Telih1,Amin Shantu1,El-Bayoumy Karam1

Affiliation:

1. Department of Biochemistry and Molecular Biology and Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, Department of Basic Sciences, New York University, and Department of Environmental Medicine, New York University Medical School, New York, New York 10019

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference34 articles.

1. Kielhorn, J., Wahnschaffe, U. and Mangelsdorf, I. (2003) A Report: Selected Nitro- and Nitro-oxy-polycyclic Aromatic Hydrocarbons, Environmental Health Criteria 229,The World Health Organization,Geneva, Switzerland.

2. Tumorigenicity of Polycyclic Aromatic Hydrocarbons: "On the Possible Contribution of PAHs and their Nitro-Derivatives to the Development of Human Breast Cancer"

3. Polycyclic nitroarenes (nitro-PAHs) as biomarkers of exposure to diesel exhaust

4. Nitro‐polycyclic aromatic hydrocarbons: A class of genotoxic environmental pollutants

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