Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds-Reference-Cited by-同舟云学术

Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds

Published:2012-09-19 Issue:10 Volume:25 Page:2067-2082
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Sakatis Melanie Z.¹,Reese Melinda J.²,Harrell Andrew W.¹,Taylor Maxine A.¹,Baines Ian A.¹,Chen Liangfu³,Bloomer Jackie C.¹,Yang Eric Y.³,Ellens Harma M.³,Ambroso Jeffrey L.⁴,Lovatt Cerys A.⁵,Ayrton Andrew D.¹,Clarke Stephen E.¹

Affiliation:

1. Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Park Road, Ware, Hertfordshire SG12 0DP, United Kingdom

2. Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Five Moore Drive, P.O. Box 13398, Research Triangle Park, North Carolina, United States

3. Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Upper Merion, 709 Swedeland Road, King of Prussia, Pennsylvania 1905, United States

4. Safety Assessment, GlaxoSmithKline, Five Moore Drive, P.O. Box 13398, Research Triangle Park, North Carolina, United States

5. Safety Assessment, GlaxoSmithKline, Park Road, Ware, Hertfordshire SG12 0DP, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx300075j

Reference44 articles.

1. Hepatotoxicity in drug development: detection, significance and solutions

2. Friedman, S. E., Grendell, J. H., and McQuaid, K. R. (2003) Current Diagnosis and Treatment in Gastroenterology, pp664–679,Lang Medical Books,New York.

3. Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science

4. KMR Pharmaceutical Benchmarking Forum, R & D General Metrics Study Presentation, 4 May 2006.

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