Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor-Reference-Cited by-同舟云学术

Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Published:2014-07-28 Issue:15 Volume:57 Page:6495-6512
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cid José María¹,Tresadern Gary¹,Duvey Guillaume²,Lütjens Robert²,Finn Terry,Rocher Jean-Philippe,Poli Sonia,Vega Juan Antonio¹,de Lucas Ana Isabel¹,Matesanz Encarnación¹,Linares María Lourdes¹,Andrés José Ignacio¹,Alcazar Jesús¹,Alonso José Manuel¹,Macdonald Gregor J.,Oehlrich Daniel,Lavreysen Hilde,Ahnaou Abdelah,Drinkenburg Wilhelmus,Mackie Claire,Pype Stefan,Gallacher David,Trabanco Andrés A.¹

Affiliation:

1. Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75, 45007 Toledo, Spain

2. Addex Therapeutics, 12 Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500496m

Reference47 articles.

1. Psychopharmacology (2005) 179:4-29

2. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors