Coupling Polymorphism/Solvatomorphism and Physical Stability Evaluation with Early Salt Synthesis Optimization of an Investigational Drug-Reference-Cited by-同舟云学术

Coupling Polymorphism/Solvatomorphism and Physical Stability Evaluation with Early Salt Synthesis Optimization of an Investigational Drug

Published:2011-05-05 Issue:3 Volume:15 Page:666-672
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Shevchenko Anna¹²,Belle David Din²,Tiittanen Saara²,Karjalainen Arto²,Tolvanen Arto²,Tanninen Veli Pekka²,Haarala Jorma²,Mäkelä Mikko²,Yliruusi Jouko¹,Miroshnyk Inna¹

Affiliation:

1. Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki FIN-00014, Finland

2. Research and Development, Orion Pharma, P.O. Box 65, FI-02101 Espoo, Finland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op200026f

Reference29 articles.

1. Designing a molecular delivery system within a preclinical timeframe

2. Accelerating Proof of Concept for Small Molecule Drugs Using Solid-State Chemistry

3. Strategies at the Interface of Drug Discovery and Development: Early Optimization of the Solid State Phase and Preclinical Toxicology Formulation for Potential Drug Candidates

4. Impact of solid state properties on developability assessment of drug candidates

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