Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity-Reference-Cited by-同舟云学术

Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity

Published:2011-05-13 Issue:22 Volume:50 Page:4903-4911
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Gay Sean C.¹,Zhang Haoming²,Wilderman P. Ross¹,Roberts Arthur G.¹,Liu Tong³,Li Sheng³,Lin Hsia-lien²,Zhang Qinghai⁴,Woods Virgil L.³,Stout C. David⁴,Hollenberg Paul F.²,Halpert James R.¹

Affiliation:

1. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States

2. Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Department of Medicine, University of California, San Diego, La Jolla, California 92093, United States

4. Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, United States

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi200482g

Reference46 articles.

1. Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications

2. Mechanistic Analysis of the Inactivation of Cytochrome P450 2B6 by Phencyclidine: Effects on Substrate Binding, Electron Transfer, and Uncoupling

3. Effect of 17-α-Ethynylestradiol on Activities of Cytochrome P450 2B (P450 2B) Enzymes: Characterization of Inactivation of P450s 2B1 and 2B6 and Identification of Metabolites

4. On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol.

5. Molecular basis for a functionally unique cytochrome P450IIB1 variant.

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