Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways-Reference-Cited by-同舟云学术

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Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways

Published:2019-09-03 Issue:9 Volume:5 Page:1614-1624
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Lee Kin Sing Stephen¹²,Yang Jun¹,Niu Jun¹,Ng Connie J.¹,Wagner Karen M.¹,Dong Hua¹,Kodani Sean D.¹,Wan Debin¹,Morisseau Christophe¹,Hammock Bruce D.¹^ORCID

Affiliation:

1. Department of Entomology and Nematology and UCD Comprehensive Cancer Center, University of California at Davis, One Shields Avenue, Davis, California 95616, United States

2. Department of Pharmacology and Toxicology and Department of Chemistry, Michigan State University, 1355 Bogue Street, East Lansing, Michigan 48824, United States

Funder

National Institute of Environmental Health Sciences

Division of Mathematical Sciences

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acscentsci.9b00770

Reference62 articles.

1. Quality guidelines for oral drug candidates: dose, solubility and lipophilicity

2. Kaitin, K. I. Causes of Clinical Failures Vary Widely by Therapeutic Class, Phase of Study; Tufts University, 2013.

3. Phase II and phase III failures: 2013–2015

4. Drug–target interaction kinetics: underutilized in drug optimization?

5. The drug–target residence time model: a 10-year retrospective

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