Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections

Author:

Czuban Magdalena12,Srinivasan Sangeetha3,Yee Nathan A.3,Agustin Edgar4,Koliszak Anna5,Miller Ethan3,Khan Irfan4,Quinones Ilenis4,Noory Hasina4,Motola Christopher4,Volkmer Rudolf6,Di Luca Mariagrazia5,Trampuz Andrej7,Royzen Maksim4ORCID,Mejia Oneto Jose M.3

Affiliation:

1. Berlin-Brandenburg Center for Regenerative Therapies and Berlin-Brandenburg School for Regenerative Therapies, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany

2. Institute of Chemistry and Biochemistry, Freie Universität, Takustr. 3, 14195 Berlin, Germany

3. Shasqi Inc., 665 Third Street, San Francisco, California 94107, United States

4. Department of Chemistry, University at Albany, 1400 Washington Avenue, Albany, New York 12222, United States

5. Berlin-Brandenburg Center for Regenerative Therapies, Augustenburger Platz 1, 13353 Berlin, Germany

6. Institute for Medical Immunology and Leibniz-Institut für Molekulare Pharmakologie, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany

7. Charité − Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Center for Musculoskeletal Surgery, Charitéplatz 1, 10117 Berlin, Germany

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

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