To 200,000 <i>m</i>/<i>z</i> and Beyond: Native Electron Capture Charge Reduction Mass Spectrometry Deconvolves Heterogeneous Signals in Large Biopharmaceutical Analytes-Reference-Cited by-同舟云学术

To 200,000 m/z and Beyond: Native Electron Capture Charge Reduction Mass Spectrometry Deconvolves Heterogeneous Signals in Large Biopharmaceutical Analytes

Published:2024-07-26 Issue:8 Volume:10 Page:1548-1561
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Le Huray Kyle I. P.¹,Wörner Tobias P.²,Moreira Tiago¹,Dembek Marcin³,Reinhardt-Szyba Maria²,Devine Paul W. A.⁴,Bond Nicholas J.⁴^ORCID,Fort Kyle L.²⁵,Makarov Alexander A.²⁵^ORCID,Sobott Frank¹^ORCID

Affiliation:

1. Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, U.K.

2. Thermo Fisher Scientific (Bremen) GmbH, Hanna-Kunath Str. 11, 28199 Bremen, Germany

3. Purification Process Sciences, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K.

4. Analytical Sciences, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K.

5. Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands

Funder

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.4c00462

Reference100 articles.

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5. Heptameric (L12)6/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria

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