Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells

Author:

Truex Nicholas L.12ORCID,Rondon Aurélie1ORCID,Rössler Simon L.1ORCID,Hanna Cameron C.1,Cho Yehlin3,Wang Bin-You1,Backlund Coralie M.4,Lutz Emi A.45,Irvine Darrell J.34567ORCID,Pentelute Bradley L.1489ORCID

Affiliation:

1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

2. Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, United States

3. Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

4. The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, United States

5. Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

6. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, Massachusetts 02139, United States

7. Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 20815, United States

8. Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

9. Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, Massachusetts 02142, United States

Funder

U.S. Department of Health and Human Services

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

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