Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization-Reference-Cited by-同舟云学术

Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization

Published:2022-04-27 Issue:5 Volume:8 Page:636-655
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Bhatia Sanil¹^ORCID,Spanier Lukas²,Bickel David²,Dienstbier Niklas¹,Woloschin Vitalij²,Vogt Melina¹,Pols Henrik²,Lungerich Beate²,Reiners Jens³,Aghaallaei Narges⁴,Diedrich Daniela²,Frieg Benedikt²⁵,Schliehe-Diecks Julian¹,Bopp Bertan⁶,Lang Franziska¹,Gopalswamy Mohanraj²,Loschwitz Jennifer²,Bajohgli Baubak⁴^ORCID,Skokowa Julia⁴,Borkhardt Arndt¹,Hauer Julia⁷⁸,Hansen Finn K.⁹^ORCID,Smits Sander H. J.³¹⁰,Jose Joachim⁶^ORCID,Gohlke Holger²⁵,Kurz Thomas²^ORCID

Affiliation:

1. Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany

2. Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany

3. Center for Structural Studies, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany

4. Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Tübingen 72076, Germany

5. John von Neumann Institute for Computing (NIC), Jülich Supercomputing Centre (JSC), Institute of Biological Information Processing (IBI-7: Structural Biochemistry) & Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH, Jülich 52425, Germany

6. Institute for Pharmaceutical and Medicinal Chemistry, PharmaCampus, Westphalian Wilhelms University, Münster 48149, Germany

7. Department of Pediatrics, Pediatric Hematology and Oncology, University Hospital Carl Gustav Carus, Dresden 01307, Germany

8. Partner Site Dresden, National Center for Tumor Diseases (NCT), Dresden 01307, Germany

9. Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute University of Bonn, Bonn 53121, Germany

10. Institute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany

Funder

Deutsche Forschungsgemeinschaft

Horizon 2020 Framework Programme

H2020 European Research Council

Deutsche Krebshilfe

Forschungskommission, Heinrich Heine University D?sseldorf

D?sseldorf School of Oncology, Heinrich Heine University D?sseldorf

KinderKrebsForschung e.V.

Strategischer Forschungsfonds, Heinrich Heine University D?sseldorf

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.2c00013

Reference103 articles.

1. Old and New Approaches to Target the Hsp90 Chaperone

2. The HSP90 chaperone machinery

3. Significance of heat-shock protein (HSP) 90 expression in acute myeloid leukemia cells

4. Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90–Kinase Interactions

5. Maximizing the Therapeutic Potential of HSP90 Inhibitors

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