Iridium-Catalyzed Asymmetric Cascade Allylation/Lactonization of Indole Esters: Access to Chiral Tricyclic Oxazinoindolones

Author:

Xiao Fan12,Liao Peiqin1,Lu Xiaoguang1,Wang Jin1,Dong Xiu-Qin1ORCID,Wang Chun-Jiang12ORCID

Affiliation:

1. Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P.R. China

2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai, 230021, P.R. China

Funder

Central University Basic Research Fund of China

Natural Science Foundation of Hubei Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference93 articles.

1. aAyral-Kaloustian, S.; Zhang, N.; Venkatesan, A. M.; Mansour, T. S.; Nguyen, T. H.; Anderson, J. T. [a]-Fused indole compounds, their use as mTOR kinase and PI3 kinase inhibitors for treating cancer, and their syntheses. US20090192147A1, 2009.

2. bTsou, H.R.; Birnberg, G. H.; Macewan, G. J.; Ayral-Kaloustian, S.; Bursavich, M. G.; Lombardi, S.; Zhang, N.; Gilbert, A. M.; Grosu, G. T.; Brooijmans, N.; Nguyen, T. H. Preparation of 3-substituted 1H-pyrrolo[2,3-b]pyridine and 1H-pyrrolo[3,2-b]pyridine compounds as mTOR kinase and PI3 kinase inhibitors. US20090298820A1, 2009.

3. Synthesis and evaluation of heterocycle structures as potential inhibitors of Mycobacterium tuberculosis UGM

4. dZimmerman, W. T. Herbicidal sulfonylureas. PCT Int. Appl. WO9110668A1, 1991.

5. Fused lactones as a route to functionalized 1-substituted indoles

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