Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut, and Fluorophenibut-Reference-Cited by-同舟云学术

Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut, and Fluorophenibut

Published:2020-10-07 Issue:20 Volume:22 Page:8122-8126
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Ötvös Sándor B.¹²^ORCID,Llanes Patricia³,Pericàs Miquel A.³⁴^ORCID,Kappe C. Oliver¹²^ORCID

Affiliation:

1. Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria

2. Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, A-8010 Graz, Austria

3. Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology (BIST), Av. Països Catalans 16, E-43007 Tarragona, Spain

4. Departament de Química Inorgànica i Orgànica, Universitat de Barcelona (UB), E-08028 Barcelona, Spain

Funder

Austrian Science Fund

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.orglett.0c03100

Reference85 articles.

1. 3-Substituted GABA analogs with central nervous system activity: A review

2. Classics in Chemical Neuroscience: Baclofen