Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase-Reference-Cited by-同舟云学术

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Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase

Published:2015-06-02 Issue:22 Volume:137 Page:7003-7006
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Li Yang¹,Dodge Greg J.²,Fiers William D.¹,Fecik Robert A.¹,Smith Janet L.²,Aldrich Courtney C.¹

Affiliation:

1. Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States

2. Department of Biological Chemistry and Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

National Institute of General Medical Sciences

Department of Medicinal Chemistry, University of Minnesota

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.5b02325

Reference42 articles.

1. The type I fatty acid and polyketide synthases: a tale of two megasynthases

2. An Enzyme Assembly Line

3. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products

4. Cloning and Heterologous Expression of the Epothilone Gene Cluster

5. Exploiting Enzymatic Promiscuity to Engineer a Focused Library of Highly Selective Antifungal and Antiproliferative Aureothin Analogues

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2. QM/MM study of the [4Fe-4S]-dependent (R)-2-hydroxyisocaproyl-CoA dehydratase: Dehydration via a redox pathway with an α-carbonyl radical intermediate;Journal of Catalysis;2023-05

3. Domain Truncation in Hispidin Synthase Orthologs from Non-Bioluminescent Fungi Does Not Lead to Hispidin Biosynthesis;International Journal of Molecular Sciences;2023-01-10

4. Functional analysis of the dehydratase domains of the PUFA synthase from Emiliania huxleyi in Escherichia coli and Arabidopsis thaliana;Biotechnology for Biofuels and Bioproducts;2022-11-15

5. Diene incorporation by a dehydratase domain variant in modular polyketide synthases;Nature Chemical Biology;2022-09-15

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