Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist “Trigger”-Reference-Cited by-同舟云学术

Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist “Trigger”

Published:1996-01-01 Issue:2 Volume:39 Page:562-569
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Aquino Christopher J.¹,Armour Duncan R.¹,Berman Judd M.¹,Birkemo Larry S.¹,Carr Robin A. E.¹,Croom Dallas K.¹,Dezube Milana¹,Dougherty, Robert W.¹,Ervin Gregory N.¹,Grizzle Mary K.¹,Head Julie E.¹,Hirst Gavin C.¹,James Michael K.¹,Johnson Michael F.¹,Miller Laurence J.¹,Queen Kennedy L.¹,Rimele Thomas J.¹,Smith David N.¹,Sugg Elizabeth E.¹

Affiliation:

1. Departments of Medicinal Chemistry, Cellular Biochemistry, and Pharmacology, Glaxo Wellcome, 5 Moore Drive, Research Triangle Park, North Carolina 27709, Center for Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905, and Department of Medicinal Chemistry, Glaxo Wellcome Medicines Research Center, Gunnels Wood Road, Stevenage, Herts, SG1 2NY U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm950626d

Reference27 articles.

1. Biological actions of cholecystokinin

2. C-terminal octapeptide of cholecystokinin decreases food intake in man

3. Evidence that decreased feeding induced by systemic injection of cholecystokinin is mediated by CCK-A receptors

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