Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid

Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid–Base Catalysis

Published:2021-04-28 Issue:9 Volume:11 Page:5873-5884
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Wan Qun^ORCID,Bennett Brad C.¹^ORCID,Wymore Troy²,Li Zhihong,Wilson Mark A.³^ORCID,Brooks Charles L.²^ORCID,Langan Paul⁴,Kovalevsky Andrey⁴^ORCID,Dealwis Chris G.

Affiliation:

1. Biological and Environmental Science Department, Samford University, Birmingham, Alabama 35229, United States

2. Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, Nebraska 68588, United States

4. Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, United States

Funder

Biological and Environmental Research

Basic Energy Sciences

National Natural Science Foundation of China

National Institute of General Medical Sciences

Fundamental Research Funds for the Central Universities

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.1c00417

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