QM/MM MD Simulations on the Enzymatic Pathway of the Human Flap Endonuclease (hFEN1) Elucidating Common Cleavage Pathways to RNase H Enzymes
Author:
Affiliation:
1. Institute of Research in Biomedicine (IRB), Via Vincenzo Vela, 6500 Bellinzona, Switzerland
2. CNR-IOM-Democritos National Simulation Center c/o International School for Advanced Studies (SISSA/ISAS), Via Bonomea 265, 34136 Trieste, Italy
Publisher
American Chemical Society (ACS)
Subject
Catalysis,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acscatal.5b00178
Reference107 articles.
1. The Wonders of Flap Endonucleases: Structure, Function, Mechanism and Regulation
2. Flap Endonuclease 1
3. Functional regulation of FEN1 nuclease and its link to cancer
4. Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity
5. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors
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