Minimalist Protein Engineering of an Aldolase Provokes Unprecedented Substrate Promiscuity
Author:
Affiliation:
1. Institut für Organische Chemie und Biochemie, Technische Universität Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany
2. Instituto de Quı́mica Avanzada de Cataluña-IQAC-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain
Funder
Bundesministerium für Bildung und Forschung
German Academic Exchange Service
Ministerio de Economía y Competitividad
European Cooperation in Science and Technology
Publisher
American Chemical Society (ACS)
Subject
Catalysis,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acscatal.5b02805
Reference33 articles.
1. Catalytic promiscuity and the evolution of new enzymatic activities
2. Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
3. Enzyme Promiscuity: Engine of Evolutionary Innovation
4. Minimalist Active-Site Redesign: Teaching Old Enzymes New Tricks
5. Protein promiscuity and its implications for biotechnology
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