In Silico Based Engineering Approach to Improve Transaminases for the Conversion of Bulky Substrates-Reference-Cited by-同舟云学术

In Silico Based Engineering Approach to Improve Transaminases for the Conversion of Bulky Substrates

Published:2018-10-25 Issue:12 Volume:8 Page:11524-11533
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Voss Moritz¹,Das Devashish²,Genz Maika¹,Kumar Anurag²,Kulkarni Naveen²,Kustosz Jakub¹,Kumar Pravin²,Bornscheuer Uwe T.¹^ORCID,Höhne Matthias³

Affiliation:

1. Department of Biotechnology & Enzyme Catalysis, Institute of Biochemistry, Greifswald University, Felix-Hausdorff-Str. 4, 17487 Greifswald, Germany

2. Quantumzyme, LLP, No. 110/8, Krishnappa Layout, Lalbagh Road, Bangalore 560027, India

3. Protein Biochemistry, Institute of Biochemistry, Greifswald University, Felix-Hausdorff-Str. 4, 17487 Greifswald, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.8b03900

Reference32 articles.

1. Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications

2. Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines

3. A Systematic Analysis of the Substrate Scope of (S )- and (R )-Selective Amine Transaminases

4. Active-Site Engineering of ω-Transaminase for Production of Unnatural Amino Acids Carrying a Side Chain Bulkier than an Ethyl Substituent

5. Engineering the Active Site of the Amine Transaminase fromVibrio fluvialisfor the Asymmetric Synthesis of Aryl-Alkyl Amines and Amino Alcohols

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