Rearrangement of a Cyclohexyl Radical to a Cyclopentylmethyl Radical on the Avermectin Skeleton

Author:

Kessabi Fiona Murphy1,Winkler Tammo1,Luft Jennifer A. R.1,Houk K. N.1

Affiliation:

1. Syngenta Crop Protection AG, Schwarzwaldallee 215, 4058 Basel, Switzerland, and Department of Chemistry and Biochemistry, University of California, Los Angeles 607 Charles E. Young Dr. East, Los Angeles, California 90095-1569

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference54 articles.

1. aFisher, M. H.; Mrozik, H.InMacrolide Antibiotics, (Ed.Omura S.),Academic Press, 1985, pp553.

2. bCrimmins, M. T.; Hollis, W. G., Jr.; O’Mahony, R.InStudies in Natural Product Chemistry;Atta-ur-Rahman, Ed.Elsevier, 1988; Vol. 1, p435.

3. cBlizzard, T.; Fisher, M. H.; Shin, T. L.InRecent Progress in the Chemical Synthesis of Antibiotics;Lukacs. G., Ohno M., Eds.Springer-Verlag: New York, 1990; p65.

4. The absolute stereochemistry and conformation of avermectin B2a aglycone and avermectin B1a

5. Syntheses and biological activities of 13-substituted avermectin aglycons

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