Development of a Comprehensive, Validated Pharmacophore Hypothesis for Anthrax Toxin Lethal Factor (LF) Inhibitors Using Genetic Algorithms, Pareto Scoring, and Structural Biology-Reference-Cited by-同舟云学术

Development of a Comprehensive, Validated Pharmacophore Hypothesis for Anthrax Toxin Lethal Factor (LF) Inhibitors Using Genetic Algorithms, Pareto Scoring, and Structural Biology

Published:2012-06-25 Issue:7 Volume:52 Page:1886-1897
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Chiu Ting-Lan¹,Amin Elizabeth A.¹

Affiliation:

1. Department of Medicinal Chemistry and Minnesota Supercomputing Institute for Advanced Computational Research, University of Minnesota, 717 Delaware St. SE, Minneapolis, Minnesota 55414-2959

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ci300121p

Reference74 articles.

1. Contribution of individual toxin components to virulence of Bacillus anthracis

2. Anthrax Lethal Factor Proteolysis and Inactivation of MAPK Kinase

3. Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs

4. Molecular recognitions in the MAP kinase cascades

5. Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

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