A Concise Synthesis of a Tetrahydropyrazolopyrazine Building Block

Author:

Shu Lianhe1,Wang Ping1,Gu Chen1,Garofalo Lisa1,Alabanza Lady Mae1,Dong Yan1

Affiliation:

1. Process Research and Synthesis, Pharma Early Research and Development (pRED), Hoffmann-La Roche, Inc., 340 Kingsland Street, Nutley, New Jersey 07110, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference11 articles.

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2. Barbosa, A. J. M.; Blomgren, P. A.; Currie, K. S; Krishnamoorthy, R.; Kropf, J. E.; Lee, S. H.; Mitchell, S. A.; Ortwine, D.; Schmitt, A. C.; Wang, X.; Xu, J.; Young, W; Zhang, H.; Zhao, Z.; Zhichkin, P. E.Pyridione and Aza-Pyridone Compounds and Method of Use. PCT Int. Appl. WO 2011140488, November 10, 2011;Chem. Abstr. 2011, 155, 657033.

3. Currie, K. S.; Wang, X.; Young, W. B.Pyridazinones, Method of Making, and Method of Use Thereof. PCT Int. Appl. WO 2012030990, March 8, 2012;Chem. Abstr. 2012, 156, 363039.

4. An Efficient Procedure for the Synthesis of 5H-6-Substituted-pyrazolo[1,5-d]-1,2,4-triazine-4,7-diones

5. PEG-supported synthesis of pyrazole oligoamides with peptide β-sheet affinity

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