Safe Scale-Up of Pharmaceutical Manufacturing Processes with Dimethyl Sulfoxide as the Solvent and a Reactant or a Byproduct

Author:

Wang Zhe1,Richter Steven M.1,Bellettini John R.1,Pu Yu-Ming1,Hill David R.1

Affiliation:

1. Process Research and Development, AbbVie Inc.,1 North Waukegan Road, North Chicago, Illinois 60064, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference12 articles.

1. Thermal hazards and safe scale-up of reactions containing dimethyl sulfoxide

2. DMSO Can Be More than a Solvent:  Thermal Analysis of Its Chemical Interactions with Certain Chemicals at Different Process Stages

3. Bretherick, L.Handbook of Reactive Chemical Hazards,6th ed.Butterworth-Heinemann:London, 1999; p336.

4. Report of Case Studies in the State of Tamil Nadu.http://dgfasli.nic.in/safetyhealth_info/case_studies/tamilnadu.htm.

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