A Conformationally Locked Analogue of the Anti-HIV Agent Stavudine. An Important Correlation between Pseudorotation and Maximum Amplitude-Reference-Cited by-同舟云学术

A Conformationally Locked Analogue of the Anti-HIV Agent Stavudine. An Important Correlation between Pseudorotation and Maximum Amplitude

Published:2003-06-20 Issue:15 Volume:46 Page:3292-3299
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Choi Yongseok¹,George Clifford¹,Comin Maria J.¹,Barchi, Joseph J.¹,Kim Hak Sung¹,Jacobson Kenneth A.¹,Balzarini Jan¹,Mitsuya Hiroaki¹,Boyer Paul L.¹,Hughes Stephen H.¹,Marquez Victor E.¹

Affiliation:

1. Laboratory of Medicinal Chemistry, Center for Cancer Research, NCI−Frederick, NIH, Frederick, Maryland 21702; Laboratory for the Structure of Matter, Naval Research Laboratory, Washington, D.C. 20375; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, Katholieke Universiteit Leuven, Rega Institute, Minderbroedersstraat 10, B-3000 Leuven, Belgium; Experimental Retrovirology Section, Center for...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030116g

Reference21 articles.

1. Nucleosides with a Twist. Can Fixed Forms of Sugar Ring Pucker Influence Biological Activity in Nucleosides and Oligonucleotides?

2. Conformational Analysis of Nucleosides Constructed on a Bicyclo[3.1.0]hexane Template. Structure-Antiviral Activity Analysis for the Northern and Southern Hemispheres of the Pseudorotational Cycle

3. HIV-1 Reverse Transcriptase Can Discriminate between Two Conformationally Locked Carbocyclic AZT Triphosphate Analogues

4. Synthesis of Conformationally Restricted Carbocyclic Nucleosides: The Role of the O(4′)-Atom in the Key Hydration Step of Adenosine Deaminase

Cited by 56 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis and Biological Evaluation of New Dihydrofuro[3,2-b]piperidine Derivatives as Potent α-Glucosidase Inhibitors;Molecules;2024-03-06

2. A new entrant in ketene family: Generation of 2‐(3‐Oxo‐allyl)‐isoindole‐1,3‐dione and their [4+2] Cycloadditions with 1,3‐Diazabuta‐1,3‐dienes;Asian Journal of Organic Chemistry;2023-01-04

3. Research Progress in Nucleoside Antiviral Drugs;Hans Journal of Medicinal Chemistry;2023

4. Design, Synthesis, and Characterization of Novel sn-1 Heterocyclic DAG-Lactones as PKC Activators;Journal of Medicinal Chemistry;2021-07-19

5. The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold;Antiviral Research;2018-06