Synthesis, Reduction Potentials, and Antitubercular Activity of Ring A/B Analogues of the Bioreductive Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)-Reference-Cited by-同舟云学术

Synthesis, Reduction Potentials, and Antitubercular Activity of Ring A/B Analogues of the Bioreductive Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

Published:2008-12-17 Issue:3 Volume:52 Page:637-645
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thompson Andrew M.¹,Blaser Adrian¹,Anderson Robert F.¹,Shinde Sujata S.¹,Franzblau Scott G.¹,Ma Zhenkun¹,Denny William A.¹,Palmer Brian D.¹

Affiliation:

1. Auckland Cancer Society Research Centre, School of Medical Sciences and Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand, Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, and Global Alliance for TB Drug Development, 40 Wall Street, New York, New York 10005

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801087e

Reference38 articles.

1. Current Status of Some Antituberculosis Drugs and the Development of new Antituberculous Agents with Special Reference to their In Vitro and In Vivo Antimicrobial Activities

2. 4Tuberculosis Chemotherapy: Recent Developments and Future Perspectives

3. Challenges Associated with Current and Future TB Treatment

4. Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models

5. Combination Chemotherapy with the Nitroimidazopyran PA-824 and First-Line Drugs in a Murine Model of Tuberculosis

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