Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability
Author:
Affiliation:
1. Department of Biochemistry and Molecular Genetics, and ‡Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, Illinois 60607, United States
Funder
National Cancer Institute
National Institutes of Health
Argonne National Laboratory, Office of Science
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm501124j
Reference32 articles.
1. Structure and function of cellular deoxyribonucleoside kinases
2. Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
3. Requirement for deoxycytidine kinase in T and B lymphocyte development
4. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress
5. A Deficiency in Nucleoside Salvage Impairs Murine Lymphocyte Development, Homeostasis, and Survival
Cited by 15 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Antitumoral activity of different Amaryllidaceae alkaloids: In vitro and in silico assays;Journal of Ethnopharmacology;2024-07
2. From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia;Nature Communications;2023-05-29
3. Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency;Drug Resistance Updates;2023-03
4. Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy;Cells;2022-02-20
5. STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [18F]FLT PET imaging;Proceedings of the National Academy of Sciences;2021-09-03
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3