Benzyl Isothiocyanate Ameliorates High-Fat Diet-Induced Hyperglycemia by Enhancing Nrf2-Dependent Antioxidant Defense-Mediated IRS-1/AKT/TBC1D1 Signaling and GLUT4 Expression in Skeletal Muscle

Author:

Chuang Wei-Ting1,Yen Chih-Ching23,Huang Chin-Shiu4,Chen Haw-Wen1,Lii Chong-Kuei14ORCID

Affiliation:

1. Department of Nutrition, China Medical University, 40402 Taichung, Taiwan

2. Department of Respiratory Therapy, China Medical University, 40402 Taichung, Taiwan

3. Department of Internal Medicine, China Medical University Hospital, 40447 Taichung, Taiwan

4. Department of Health and Nutrition Biotechnology, Asia University, 41354 Taichung, Taiwan

Funder

China Medical University

Ministry of Science and Technology, Taiwan

Publisher

American Chemical Society (ACS)

Subject

General Agricultural and Biological Sciences,General Chemistry

Reference59 articles.

1. Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation

2. Dyslipidemia in Obesity: Mechanisms and Potential Targets

3. World Health Organization Obesity and diabetes: the slow-motion disaster Keynote address at the 47th meeting of the National Academy of Medicine. http://www.who.int/dg/speeches/2016/obesity-diabetes-disaster/en/.

4. Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes

5. Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

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