mTORC1 and mTORC2 Co-Protect against Cadmium-Induced Renal Tubular Epithelial Cell Apoptosis and Acute Kidney Injury by Regulating Protein Kinase B-Reference-Cited by-同舟云学术

mTORC1 and mTORC2 Co-Protect against Cadmium-Induced Renal Tubular Epithelial Cell Apoptosis and Acute Kidney Injury by Regulating Protein Kinase B

Published:2024-09-02 Issue:36 Volume:72 Page:19667-19679
ISSN:0021-8561
Container-title:Journal of Agricultural and Food Chemistry
language:en
Short-container-title:J. Agric. Food Chem.

Author:

Zhu Jiaqiao¹²³,Gong Zhonggui¹⁴⁵,Wang Xueru¹²³,Zhang Kanglei¹²³,Ma Yonggang¹²³,Zou Hui¹²³,Song Ruilong¹²³,Zhao Hongyan¹²³,Liu Zongping¹²³^ORCID,Dong Wenxuan¹⁶

Affiliation:

1. College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, China

2. Institute of Agricultural Science and Technology Development (Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China), Yangzhou University, Yangzhou, Jiangsu 225009, China

3. Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China

4. Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta of Shandong Province, Dongying, Shandong 257000, China

5. National Technological Innovation Center for Comprehensive Utilization of Saline-Alkali Land, Dongying, Shandong 257000, China

6. Laboratory of Animal Nutrition Metabolic and Poisoning Diseases, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong 266109, China

Funder

National Key Research and Development Program of China

Natural Science Foundation of Qingdao Municipality

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

Postdoctoral Research Funding of Yangzhou University

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.4c05702

Reference37 articles.

1. From AKI to CKD: Maladaptive Repair and the Underlying Mechanisms

2. SIRT1 alleviates Cd nephrotoxicity through NF-κB/p65 deacetylation–mediated pyroptosis in rat renal tubular epithelial cells

3. Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery

4. Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury

5. N-acetylcysteine delayed cadmium-induced chronic kidney injury by activating the sirtuin 1–P53 signaling pathway